Every clinical trial comes down to two questions.
You can have a perfectly designed protocol, a well-resourced site, and a strong PI. None of it matters if you can't answer both.
Finding Patients
Most patients who would qualify for a trial never hear about it. The pipeline problem isn't just a recruitment inefficiency — it's a structural failure in how trials reach eligible individuals.
- 80% of trials fail to meet enrollment timelines
- Phase III delays cost $600K–$8M per day
- The majority of eligible patients are never identified
Keeping Them Engaged
Flusso Engage is your participants' trial companion — designed to make research fit into everyday life. Instead of dedicated portals and emailed survey links, trial activities live alongside healthcare conversations in one encrypted app. They see:
- Dropout rates routinely exceed 30%
- Survey completion sits at 60–70% industry-wide
- Every dropout wastes recruitment investment and weakens statistical power
- No meaningful connection between site visits
The problem isn't one-sided. It affects everyone.
Both sides want the same thing. Researchers want participants who stay engaged and complete the trial. Participants want to contribute to research that matters — they just don't want the friction. The gap between "we want to do this" and "the system makes it too hard" is where 30% dropout rates come from.
What Research Teams Face
Can't reach participants between visits
Calls go unanswered. No feedback until the next scheduled visit — by which time participants may have already silently withdrawn.
Survey completion rates below 60%
ePRO instruments sit untouched. Valuable patient-reported outcomes data missing. Study endpoints at risk.
No early warning for dropout
Coordinators discover disengagement only after participants have already left — no chance to understand why or intervene.
Fragmented systems with no unified view
Site coordinators jump between enrollment systems, safety databases, survey platforms, and appointment schedulers — with no single dashboard for trial operations.
What Participants Face
Another portal to download
They already use a GP app, a hospital portal, a pharmacy app, and a wearable app. A trial portal? That's one app too many.
Consent forms in legal language
40 pages of dense legalese. Participants don't understand what they're enrolled in or what they're actually consenting to.
Forgotten logins and poor UX
They sign up, can't remember the password a week later, and don't go through the friction of resetting it. The trial disappears from their life.
Feel like a data point, not a person
Generic automated messages. No sense that someone cares about their progress. Surveys that ask the same questions again and again without explaining why.
Configured in Participate. Delivered through Engage.
Most clinical trial platforms treat the participant experience as an afterthought — "here's a portal, log in and take the survey." Flusso built the participant experience first, then built the researcher tools to configure what participants would see. That's why the expected outcomes are so different.
Participate — Your Command Center
You configure everything your trial needs in a single dashboard:
- Protocol setup: arms, randomisation, endpoints, inclusion/exclusion criteria
- Visit schedules and assessment windows
- Survey instruments and ePRO assessment schedules
- Safety monitoring rules and alert thresholds
- Site coordination and monitoring workflows
- Real-time enrolment and retention dashboards
- Multi-site audit trails and compliance reporting
Everything you configure becomes live the moment you publish. No backend work. No delays.
Engage — Their Companion App
Participants experience your trial through the app they already trust — the one they use for GP messages, appointment reminders, and health coordination. They see:
- Survey notifications integrated into their normal message stream
- Plain-language consent explaining exactly what you're measuring and why
- Visit reminders timed to when they'd actually appreciate them
- Messages from their trial team when there's something important to say
- A way to ask questions without worrying if someone will respond
From PDF to configured trial system in minutes. Not weeks. Not months.
A sponsor receives a 200-page protocol document. Someone needs to manually enter treatment arms, randomisation parameters, primary and secondary endpoints, inclusion/exclusion criteria, visit windows, safety monitoring parameters, and IRB tracking requirements. A single coordinator spends 2–4 weeks translating a PDF into a working trial system. During those weeks, recruitment hasn't started. Sponsors are losing money. Sites are waiting.
This isn't OCR on protocol PDFs. This is medical domain AI trained on thousands of trial protocols — understanding the semantic meaning of "randomisation 1:1 parallel arms" or "stratified by age quartile." Every extracted element receives a confidence score (95%, 87%, 72%). You review high-confidence items and spend focused time only on anything below your threshold.
Manual Setup Today
2–4 weeks of coordinator time translating a PDF into a working trial system. Error-prone. Costly. Delaying recruitment every single time.
Participate AI Import
20 minutes of AI extraction + 1–2 hours of human verification = ready for recruitment the next business day.
Value at Stake
10–14 days saved per trial. At $600K–$8M per day in Phase III delay costs, this is a $6–$112 million value play per trial.
Three core workflows. Configured once. Running forever.
These three workflows handle 90% of the operational work in a clinical trial — designed around how people actually work, not how legacy systems dictate. Everything flows through Participate, and every participant communication flows through Engage.
Surveys & ePRO
Design patient-reported outcome instruments in the survey builder — from scratch or cloned from your shared library. Participants receive a notification in their healthcare inbox, see plain-language context about why you're asking, and complete the survey in 2–3 minutes.
Response rate: 85%+ because it's integrated into an app they use daily. Missing data flagged immediately — not at database lock.
Messaging & Communication
Protocol updates reach participants as messages from their trial team — appearing in the same thread where they coordinate with their GP. Participants can reply with questions, connected directly to their patient record in Participate.
All messages are end-to-end encrypted using the Olm protocol. Even Flusso cannot read them. Only the sender and recipient see the content.
Visits & Scheduling
Configure visit schedules with screening, baseline, follow-up, and end-of-study windows. Engage sends intelligent reminders timed to each participant's preferences. Site coordinators see confirmations, flag at-risk participants, and manage rescheduling — all in one view.
If a participant needs to reschedule, they propose a time through Engage. The site coordinator approves it in Participate. Both parties are updated instantly.
The metrics that matter to your business.
Faster Time to Recruitment
Today: 4–6 weeks from approved protocol to first patient enrolled — with manual data entry, rebuilt assessment instruments, and slow site activation.
With Participate: Protocol configured in minutes. Shared survey library eliminates rebuilding instruments. AI recruitment engine with diversity dashboards surfaces qualified candidates before active recruitment begins.
Expected Result: First patient enrolled in 2–3 weeks instead of 6–8. In Phase III trials, every week counts.
Better Retention & Compliance
Today: 25–30% participant dropout, majority occurring in the first 8 weeks — driven by disconnection, not disinterest.
With Participate: Contextual consent builds trust from Day 0. Engagement through Engage keeps participants connected between visits. Dropout prediction flags disengaged participants so sites can intervene before it's too late.
Expected Result: Dropout under 10%, study completion rates above 85%. Larger samples. Better data. Smaller margins of error.
Lower Site Coordination Costs
Today: Sites spend 50%+ of coordinator time on administrative outreach — reminder calls, scheduling coordination, enrollment tracking, data entry across fragmented systems.
With Participate: Automated reminders. One unified dashboard. Immutable audit trails. REDCap bidirectional sync eliminates double entry.
Expected Result: Coordinators spend their time on care coordination and science, not administrative busywork. Site satisfaction goes up. Site retention goes up.
Faster Multi-Site Data Agreements
Today: 6–12 months to negotiate data access agreements across trial sites, with individual legal review and site IRB approval for each data use agreement.
With Participate: Pre-built Contextual Integrity governance norms for multi-site collaboration. Sites agree to CI norms once; data sharing requests within those norms auto-approve. No per-site negotiation.
Expected Result: Data agreements in 6 weeks instead of 6 months. Interim analyses run on schedule. Safety signals detected in real time.
Site Financial Visibility and Budget Control
Today: Site budgets tracked in spreadsheets. Payment milestones managed manually. No real-time view of burn rate across sites. Budget overruns discovered at reconciliation, not in real time.
With Participate: Per-site budget configuration with line items, templates, and approval workflow. Study-level budget planning and tracking across your entire portfolio. Invoicing and reimbursement management built into the platform — not a separate finance system Budget data lives alongside enrolment and operational data, so you can see cost-per-patient and burn rate in context.
Expected Result: Financial oversight moves from quarterly spreadsheet reviews to real-time dashboards. Budget overruns are flagged early. Site payments are tracked against milestones, not managed in email threads.
What research teams actually care about.
Sites choose platforms based on three things: does it make my job easier, does it work reliably, and do I have support when I get stuck. Participate delivers on all three — designed from the ground up with research coordinators in the room.
Simpler Site Onboarding
Intuitive interfaces designed by people who understand research workflows. Pre-built templates from previous trials mean you're not starting from zero on every new study. Sites are productive on Day 1. Fewer support tickets. Fewer errors.
Better data quality because the platform doesn't force workarounds.
Real-Time Enrollment Visibility
Live enrollment dashboards by site, by arm, by demographic. Diversity dashboards tracking recruitment against pre-defined targets. Protocol deviation tracking in real time. Budget tracking alongside operational data — your site knows its burn rate, payment milestones, and reimbursement status without chasing the sponsor's finance team
You course-correct fast — not at the 6-month audit.
Less Burden on Coordinators
Automated reminders from Engage eliminate 20 manual calls per week. One unified dashboard instead of four systems. Smart scheduling reduces scheduling back-and-forth. REDCap bidirectional sync — no double entry.
Coordinators get time to do the job they trained for.
Decentralised & Home-Based
Virtual visits are first-class — built into visit scheduling natively. Home visit coordination, remote assessment instruments, and hybrid trial support are standard. For rare disease trials, this is a game-changer — you can build cohorts that were impossible with site-only recruitment.
Built for modern research. Not legacy workflows.
This comparison matters because it's honest. Veeva has eTMF. Medidata has RTSM. Participate doesn't — yet. But what Participate does have, and what enterprise platforms literally cannot add without architectural reconstruction, is worth understanding clearly.
Honest about where we are. Confident about where we're going.
Privacy built into the architecture. Not bolted on as a feature.
Every security review Flusso goes through raises the same question: "Can you give us access to participant messages if needed?" The answer is no — architecturally, we cannot. Even if law enforcement shows up with a warrant, we cannot read messages because we never had access to the keys. That's not a policy. That's architecture.
🔐 Zero-Trust Encryption
All messages are encrypted end-to-end using the Olm protocol — the same cryptography Signal uses. Encryption keys live on participant and researcher devices only. Flusso never handles keys, never stores keys, never can decrypt messages even if compelled by law enforcement. No other clinical trial platform or CTMS offers this level of encryption.
🏛️ Contextual Integrity Architecture
Access control is built on Contextual Integrity — a privacy framework with 20 years of peer-reviewed research. 82+ database schema tables implement the CI framework. Every data access is validated against contextual norms before it happens across three tiers: transmission principle, information type, and participant expectations. Violations are technically impossible.
🌐 Regulatory Alignment
Built to comply with healthcare and research regulation across jurisdictions: HIPAA, GDPR, PDPA, PIPL, NHMRC National Statement, ICH E6(R3), 21 CFR Part 11, TGA GCP. When new regulations come into effect, we update configuration — not architecture. Contextual Integrity as a foundation is why regulatory changes don't require code changes.
📋 Immutable Audit Trail
Every data access, every consent decision, every governance evaluation is logged and timestamped in an immutable ledger. Participants can see their own audit trail — they know who accessed their data, when, and why. When ethics committees or regulators ask "who accessed this data?", the answer is a timestamped log that's been immutable since creation.
What changes when you eliminate the friction that causes dropout and delay.
Participant and research team targets are based on the specific friction points our architecture eliminates. We validate these during every pilot engagement.
From first conversation to live trial in weeks.
We designed the pilot structure to match how research teams actually make platform decisions. You're not signing a three-year contract on faith. You're saying: "Let's test this on our next trial and see if the metrics improve." If they do, you expand. If they don't, you walk away without having disrupted your infrastructure.
Step 1: Discovery Call — 30 Minutes
We're not selling — we're listening. We want to understand your trial, what's making your current process painful, and what your success metrics are. We come prepared with a tailored walkthrough focused on your use case: AI protocol import and multi-site analytics for Phase III sponsors; observational workflows and patient registry for research institutions. By the end, you know exactly which Participate features matter most for your work.
Step 2: Pilot Programme — 4–8 Weeks
You pick one trial and run it on Participate. Our onboarding team configures your protocol (or you do — we support both). Your sites begin using Participate and Engage for participant communication. We track enrollment rate, retention, survey completion, and coordinator workload, with weekly check-ins. You're measuring: Did enrollment move faster? Are survey completion rates higher? Are coordinators actually spending less time on admin? The pilot is low-risk because you're testing on one trial, not migrating your entire portfolio.
Step 3: Scale Across Your Portfolio
By the end of your pilot, you'll have data showing whether Participate moved your metrics. If it did, you scale. New trials onboard faster because coordinators are already trained. The shared survey library grows — instruments already built, not rebuilt. Multi-site collaboration becomes routine. The platform is designed to grow with you — Participate, Engage, and Data Coalitions share the same infrastructure — so adding a second product doesn't require a new implementation.
Sponsors using Participate can activate Engage for participant recruitment with no additional integration work. Health systems using Engage for care coordination can add Participate for observational studies without migrating data or retraining staff.
Week 1
Discovery call, pilot protocol configured, sites trained
Weeks 2–4
Pilot trial recruiting, first surveys deployed, metrics tracking begins
Weeks 4–8
Analyse metrics, evaluate platform performance, decide on commitment
Month 3+
New trials onboarding at faster velocity; portfolio-wide adoption underway
Governance That Travels. Data That Doesn't.
Clinical trials shouldn't be this hard. Patients shouldn't feel like data points. Researchers shouldn't spend half their time on paperwork. Sites shouldn't coordinate across five fragmented systems. Flusso Participate changes that.
Your research team gets a command center where they configure protocols, design surveys, schedule visits, and monitor retention — all from one platform. Participants get a companion app — the healthcare inbox they already trust — where they engage with your trial naturally, without friction. The governance layer makes violations impossible. Data agreements that used to take 18 months now take 6 weeks.
Enrollment Moves Faster
AI protocol import eliminates weeks of manual setup. Recruitment through Engage reaches participants where they already are.
Retention Improves Dramatically
Participants stay enrolled because they experience your trial through an app they use daily, with transparent consent they actually understand.
Multi-Site Collaboration Unlocked
Data agreements in 6 weeks instead of 18 months. Interim analyses across sites in real time. Research that was impossible last year becomes routine this year.
"We're not asking for a three-year commitment today. We're asking for 30 minutes to understand your research. Then we'll show you how Participate solves your specific problems."
🌐 Website
📅 Book a Call
Schedule your 30-minute discovery session directly with our clinical solutions team
Whether you're a sponsor running Phase III trials, a CRO coordinating 50 concurrent studies, a research institution managing observational and interventional work, or a trial site drowning in administrative overhead — Participate is built for you. Governance that travels. Data that doesn't. Clinical trials that patients complete.
Find patients. Keep them engaged. One integrated platform.